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Her 3-year-old son, Ben, had suffered from epileptic seizures since he was 3 months old, a result of a brain malformation called polymicrogyria. Over the years, Jacobson and her husband, Aaron, have tried giving him at least 16 different drugs, but none provided lasting relief. They lived with the grim prognosis that their son — whose cognitive abilities never advanced beyond those of a 1-year-old — would likely continue to endure seizures until the cumulative brain injuries led to his death.
In early , when Jacobson learned about cannabis at a conference organized by the Epilepsy Therapy Project, she felt a flicker of hope. The meeting, in downtown San Francisco, was unlike others she had attended, which were usually geared toward lab scientists and not directly focused on helping patients. They also included, on one day of the event, families of patients with epilepsy.
The tip came from a father named Jason David, with whom Jacobson began talking by chance outside a presentation hall. The idea to try cannabis extract came to David after he found out that the federal government held a patent on cannabidiol , a molecule derived from the cannabis plant that is commonly referred to as CBD.
But in the late s, scientists at the National Institutes of Health discovered that it could produce remarkable medicinal effects. In test tubes, the molecule shielded neurons from oxidative stress, a damaging process common in many neurological disorders, including epilepsy.
Jacobson had a Ph. She had started her postdoctoral research at the University of California, San Francisco, by studying how cancer cells metastasize and spread, but after Ben was born, she moved to Stanford and switched her focus to epilepsy — a shift that compounded her anguish. She often wept in the parking lot before heading into the lab, overwhelmed by dread at the prospect of deliberately causing epilepsy in rodents.
After meeting David and reading through the small body of published work on CBD, Jacobson changed postdoctoral directions once again, from primary research to the study of this community of parents who were treating their epileptic children with cannabis extracts. In reality, she was preparing to join it herself.
One small, double-blind study particularly caught her attention. In , scientists in Brazil treated eight epileptic patients with CBD and eight patients with sugar pills as a placebo. For half the group that received CBD, the seizures almost completely disappeared; another three experienced a reduction in the intensity of their seizures. Only one person in the placebo group got better. The epilepsy drugs that had been approved to date, none of which had helped Ben much, typically targeted the same few ion channels and receptors on the surface of neurons.
But CBD worked on different and still somewhat mysterious pathways. If she could find a suitable CBD extract, Jacobson thought, she might have a truly new class of drug for Ben.
The other experimental drugs and devices she had heard about at epilepsy conferences were under development, unapproved by the F.
But medical marijuana had been legal in California since , so CBD was theoretically accessible right away. Seven years later, cannabidiol is everywhere. Many of these products are vague about what exactly CBD can do. The F. A confluence of factors has led to this strange moment. Plenty of legitimate, if still inconclusive, research is being done on CBD. Many scientists are truly excited about it. The laws governing cannabis and its chemical components have loosened up.
Other parents of epileptic children were using D. Some reported positive results. Over the years, Jacobson has had many of these products tested at labs; almost invariably they contained very little or no CBD and too much THC.
He was at high risk of what epileptologists call Sudep , or sudden unexpected death in epilepsy. And so one day in she found herself driving her black S. In the early s, a Bulgarian-born Israeli chemist named Raphael Mechoulam asked a simple question: How does marijuana make you high? The biochemistry of major psychoactive molecules from other recreationally used drugs, like cocaine and opium, was already understood.
Mechoulam was the first scientist to map the chemical structure of both cannabidiol and deltatetrahydrocannabinol, or THC. Two decades later, Allyn Howlett, a scientist then at St. Louis University Medical School, used a radioactive THC equivalent to trace where cannabinoids ended up in the brain and discovered what she would later call CB1 receptors.
They were subsequently found in the kidneys, lungs and liver, too. White blood cells of the immune system, the gut and the spleen also have another type of cannabinoid receptor, known as CB2. There is a long history of scientists gaining insight into human physiology by studying how plants interact with our bodies.
Nicotine, a stimulant found in tobacco, long used by Native Americans, taught scientists about the existence of our own nicotinic receptors, which influence neuronal excitement. Why plants produce molecules that seem perfectly designed to manipulate human biochemical circuitry is a mystery. It could be a kind of molecular coincidence. But many plants, including cannabis, might make these molecules to defend themselves from other organisms.
Modern industrial agriculture employs a whole class of pesticides based on nicotine — the neonicotinoids — meant to repel insects by over-exciting their nervous systems. Cannabinoids display antibacterial, antifungal and insecticidal properties as well. Their ability to engage our native cannabinoid receptors may be a result of millions of years of biochemical warfare directed at would-be grazers: insects and other creatures that happen to share biochemical signaling pathways with humans.
Otherwise, why interfere with them? Mechoulam concluded that our bodies must produce their own cannabinoids — endogenous molecules that, like the native opioids and nicotinelike molecules our bodies also make, engage the cannabinoid receptors throughout the human body.
In , he identified the first one. The native network of cannabinoid receptors and transmitters described by Howlett and Mechoulam is now known as the endocannabinoid system. If a person is injured, for example, native cannabinoids increase, presumably in order to resolve the inflammation and other damage signals associated with injury.
Endocannabinoids help regulate immune activity, appetite and memory formation, among many other functions. Heavy marijuana use is associated with memory deficits, possibly because THC short-circuits the formation of memories. But realizing such medical benefits has proved trickier than once imagined. Rimonabant was first released in Europe in Two years later, regulators pulled it from the marketplace because of its severe side effects, including depression and suicidal behavior.
Attempts to increase native cannabinoids with synthetic drugs have fared no better. In , French scientists halted a study of a drug designed to boost endocannabinoids. For reasons that remain unclear, six patients who took the medicine, meant to treat pain, were hospitalized. One died. And yet, for millenniums people have used cannabis itself with relatively few side effects. These can include dry mouth, lethargy and paranoia.
With more than 65 cellular targets, CBD may provide a kind of full-body massage at the molecular level. Modern neuroscience often tries to target one pathway or receptor, Hurd told me; that approach is easier to study scientifically, but it may not address what are often network-wide problems. Cannabis has been used medicinally for thousands of years in Asia, where it was probably first domesticated before traveling to, among other places, Africa.
White Americans also had some history of using cannabis in tinctures. He began experimenting and found it quite efficacious not only for infantile seizures but also rheumatism and spasms caused by tetanus. Garcia Da Orta, a Portuguese physician, had, after living in India, written about cannabis as medicine in the s.
Researchers suspect that these older cannabis cultivars, and the tinctures made from them, probably contained much less THC and much more CBD than modern varieties. Of course, hemp, a variety of cannabis bred not for consumption but for the fiber that goes into ropes and sails, among other things, had been an important crop in Europe and the Americas for centuries.
George Washington grew it. But in the late 19th century, our ancient relationship with this plant began to fray. In , Harry Anslinger, a former official at the Bureau of Prohibition, assumed a new job running the Bureau of Narcotics. The Mexican Revolution that began in had led to waves of immigrants crossing into the United States.
Whereas many Americans took their cannabis orally in the form of tinctures, the new arrivals smoked it, a custom that was also moving north from New Orleans and other port cities from which African-Americans were beginning their own migration.
Anslinger disdained Mexican-Americans and African-Americans. He loathed jazz. Modern scholars argue that his demonizing cannabis both justified his position and provided a way for him to gain legal leverage over peoples he despised.
His protestations still echo today. Cannabis made people crazy, violent and prone to criminal behavior, Anslinger said. Yet when 30 American Medical Association members were surveyed, starting in , 29 disagreed with claims about the dangers posed by cannabis. In , Congress passed the Marijuana Tax Act. A plant that people had used medicinally for thousands of years was now driven underground. With her black-market stash in hand, Jacobson entered what she calls her R.
She set up a lab in her garage — and then proceeded to fail miserably, for months, to extract anything of much use. Only under the tutelage of two University of California, Davis, scientists did she make progress.
The technique she developed required heating cannabis plants in ethanol to extract the cannabinoids. Next, a machine that created a vacuum sucked the green-tinted liquid through a tube filled with carbon powder. Then she heated the resulting green solution until the alcohol evaporated, leaving a green paste. It took her about six months to perfect the process. Ben improved somewhat after taking it, but it was another boy with severe epilepsy, year-old Sam Vogelstein, who responded most significantly.
But now Jacobson felt a different sort of pressure. Making the medicine was difficult. Despite all that she had learned, some batches of her extract were unusable.
CVS offers a wide range of products made using hemp as well as CBD oil. Hemp Seed Supplements. Hemp seeds are packed with essential nutrients and can be. CBD oil in CVS pharmacy? Learn about CBD gum, CBD mints & how CVS is taking on CBD oil products in certain states.
As the CBD industry coasts towards a brightly positive future following the passage of the Farm Bill, a new purchasing avenue is opening up and it will give people across the country much easier access to CBD oil : the CVS Pharmacy. Since recent months have produced astounding results for the CBD industry and its fight to legalize the compound, more and more establishments, brands, and organizations are offering CBD products. And the latest to join this troupe is CVS Pharmacies.
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This is a sure sign that CBD has entered the mainstream, just a few years after it was dismissed as nothing more than a fad and a novelty item. It has over 10, locations in the U. It is also important to note that neither edibles nor CBD-derived supplements will be available.
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CVS will also be partnering with a company to test and verify the quality of the CBD topicals sold in its drug stores. CBD, or cannabidiol, comes from the hemp plant, a close relative to another member of the cannabis family, marijuana. Both plants contain abundant types of cannabinoids, but marijuana is high in the psychoactive chemical THC, while hemp is rich in CBD, the non-psychoactive component of cannabis that has generated quite a buzz for its potential medicinal benefits. CBD has been touted as a treatment for a wide range of conditions — including anxiety, pain, inflammation and even cancer — but little reliable research has been done on CBD's effects on humans, experts say. The only FDA-approved CBD oil is Epidiolex, an oral solution prescribed for the treatment of seizures associated with two rare, severe forms of epilepsy.
Some CVS stores selling topical products infused with cannabis extract CBD but not edibles
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Her 3-year-old son, Ben, had suffered from epileptic seizures since he was 3 months old, a result of a brain malformation called polymicrogyria. Over the years, Jacobson and her husband, Aaron, have tried giving him at least 16 different drugs, but none provided lasting relief. They lived with the grim prognosis that their son — whose cognitive abilities never advanced beyond those of a 1-year-old — would likely continue to endure seizures until the cumulative brain injuries led to his death. In early , when Jacobson learned about cannabis at a conference organized by the Epilepsy Therapy Project, she felt a flicker of hope. The meeting, in downtown San Francisco, was unlike others she had attended, which were usually geared toward lab scientists and not directly focused on helping patients. They also included, on one day of the event, families of patients with epilepsy. The tip came from a father named Jason David, with whom Jacobson began talking by chance outside a presentation hall. The idea to try cannabis extract came to David after he found out that the federal government held a patent on cannabidiol , a molecule derived from the cannabis plant that is commonly referred to as CBD. But in the late s, scientists at the National Institutes of Health discovered that it could produce remarkable medicinal effects. In test tubes, the molecule shielded neurons from oxidative stress, a damaging process common in many neurological disorders, including epilepsy.
