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Food products containing cannabis extract edibles have emerged as a popular and lucrative facet of the legalized market for both recreational and medicinal cannabis. The many formulations of cannabis extracts used in edibles present a unique regulatory challenge for policy makers. The most prominent difference between ingestion and inhalation of cannabis extracts is the delayed onset of drug effect with ingestion. Consumers often do not understand this aspect of edible use and may consume a greater than intended amount of drug before the drug has taken effect, often resulting in profoundly adverse effects. Written for the educated layperson and for policy makers, this paper explores the current state of research regarding edibles, highlighting the promises and challenges that edibles present to both users and policy makers, and describes the approaches that four states in which recreational cannabis use is legal have taken regarding regulating edibles. To provide a better understanding of the implications of increased use of edible cannabis products, we describe promises and challenges associated with use of cannabis-infused edibles and critically examine extant research on factors related to their use. We have blended science and regulatory factors in order to provide an overview of edibles for the educated layperson and for policy makers. Although some of the issues discussed are relevant for other methods of cannabis use e. Further, our discussion primarily focuses on consequences of intentional use of edibles in adults. Marijuana or cannabis is the most commonly used illicit drug in the United States, with 9. Further, the population of users is increasing, a finding that is associated with decreased perception of harm from cannabis use Johnston et al. As additional initiatives to decrease or eliminate criminal penalties for possession of small amounts of cannabis are already pending in several states, this trend is likely to continue, at least in the short term. In , California became the first state to legalize medicinal use of cannabis. By April , 24 states and the District of Columbia had passed laws that allow medicinal use, and four states Alaska, Colorado, Oregon, and Washington had legalized recreational use, with several other states likely to vote on legalization later in The District of Columbia has decriminalized the possession of cannabis in amounts of 2 ounces or less but has not established a regulatory framework that allows for recreational cannabis sales D.
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